2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

Related Products

PDF 4.86 MB

Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10388
    TTA-Q6
    		Antagonist 99.97%
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, which can be used in the research of neurological disease.
    TTA-Q6
  • HY-108335
    Sipatrigine
    		Inhibitor 99.63%
    Sipatrigine (619C89), a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has the potential in the study for focal cerebral ischemia and stroke.
    Sipatrigine
  • HY-128696
    Amlodipine aspartic acid impurity
    		99.23%
    Amlodipine aspartic acid impurity (Amlodipine aspartate) is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension.
    Amlodipine aspartic acid impurity
  • HY-N2005
    Cycleanine
    		Inhibitor 99.80%
    Cycleanine is a potent vascular selective Calcium antagonist. Cycleanine has analgesic, muscle relaxant and anti-inflammatory activities. Cycleanine has potential for anti-ovarian cancer acting through the apoptosis pathway.
    Cycleanine
  • HY-107322S
    Barnidipine-d5 hydrochloride
    		Antagonist ≥98.0%
    Barnidipine-d5 (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors.Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action.
    Barnidipine-d<sub>5</sub> hydrochloride
  • HY-B0317D
    (R)-Amlodipine
    		Control 99.45%
    (R)-Amlodipine is the R-Enantiomer of Amlodipine (HY-B0317)
    (R)-Amlodipine
  • HY-W344044
    Levomepromazine maleate
    		Inhibitor 99.92%
    Levomepromazine maleate (Methotrimeprazine maleate) is an N-substituted phenylthiazine antipsychotic sedative that blocks multiple receptors. Levomepromazine maleate is a potent inhibitor of CYP2D6 and is useful in the study of schizophreni.
    Levomepromazine maleate
  • HY-107349
    Fenoverine
    		Inhibitor 99.69%
    Fenoverine (Spasmopriv) is an antispasmodic agent and inhibits calcium channel currents. Fenoverine induces rhabdomyolysis.
    Fenoverine
  • HY-B0317S1
    Amlodipine-d4
    		Antagonist 98.46%
    Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317). Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.
    Amlodipine-d<sub>4</sub>
  • HY-106449
    Recoflavone
    		Inducer ≥98.0%
    Recoflavone (DA-6034 (free acid)), a synthetic derivative of the flavonoid Eupatilin (HY-N0783), is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca(2+)]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury.
    Recoflavone
  • HY-121604
    (Rac)-MEM 1003
    		Inhibitor 99.64%
    (Rac)-MEM 1003 is the racemate of MEM 1003. MEM 1003, a dihydropyridine compound, is a potent L-type Ca2+ channel antagonist and has the potential for Alzheimer’s disease research.
    (Rac)-MEM 1003
  • HY-W032013S
    1-Octanol-d17
    		99.09%
    1-Octanol-d17 is the deuterium labeled 1-Octanol. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.
    1-Octanol-d<sub>17</sub>
  • HY-17412S1
    Minocycline-d6 sulfate
    		Activator
    Minocycline-d6 sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect.
    Minocycline-d<sub>6</sub> sulfate
  • HY-12502
    Efonidipine
    		Inhibitor 99.88%
    Efonidipine(NZ-105) is a dual T-type and L-type calcium channel blocker (CCB).
    Efonidipine
  • HY-150135B
    D-myo-Inositol 1,4,5-trisphosphate tripotassium
    		Activator 98.00%
    D-myo-Inositol 1,4,5-trisphosphate tripotassium, a second messenger, elicits Ca2+ mobilization. D-myo-Inositol 1,4,5-trisphosphate tripotassium inhibits the binding of phosphoinositide-specific phospholipase C-delta 1 (PLC-delta 1) to bilayer membranes composed of phosphatidylcholine (PC) and phosphatidylinositol 4,5-bisphosphate (PIP2).
    D-myo-Inositol 1,4,5-trisphosphate tripotassium
  • HY-B0124S
    Zonisamide-d4
    		Inhibitor 99.38%
    Zonisamide-d4 is the deuterium labeled Zonisamide. Zonisamide (AD 810) is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease.
    Zonisamide-d<sub>4</sub>
  • HY-14744
    Levamlodipine
    		Inhibitor 98.53%
    Levamlodipine ((S)-Amlodipine) is a powerful dihydropyridine calcium channel blocker, possessing vasodilation properties and used in the treatment of hypertension and angina.
    Levamlodipine
  • HY-10341C
    Fasudil dihydrochloride
    		Antagonist 99.98%
    Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil dihydrochloride
  • HY-113919
    Nothofagin
    		Inhibitor ≥98.0%
    Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.
    Nothofagin
  • HY-P6013A
    wt hMLN TFA
    		Inhibitor
    wt hMLN (TFA) is a microprotein that inhibits of SR Ca2+ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.
    wt hMLN TFA
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.